Ipamorelin 10mg & 5mg (5mg Vial)
$64.00
A selective growth-hormone-releasing pentapeptide (ghrelin/GHS-R1a agonist), supplied as sterile lyophilized powder for in-vitro endocrinology research.
In stock
Tested by Freedom Diagnostics TestingHPLC purity + LC-MS identityLot-matched COA on-site
For research use only. This product is a laboratory research chemical. It is not for human or veterinary use, not a drug, supplement, or food, and not intended to diagnose, treat, cure, or prevent any disease. Sold only to qualified researchers and institutions.
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) that acts as a selective agonist of the growth-hormone secretagogue receptor (GHS-R1a, the ghrelin receptor). It stimulates pulsatile growth-hormone release from pituitary somatotrophs without significant effect on ACTH, cortisol or prolactin in published models — the basis for its classification as a ‘selective GHRP’.
Research areas where laboratories buy ipamorelin for in vitro work include GHS-R1a receptor-binding and activation assays in receptor-expressing cell lines, pituitary somatotroph GH-release studies in cell-culture and rodent models, comparative GHRP-versus-GHRH secretagogue synergy experiments, and calcium-mobilization and Gq/PLC signaling assays. The material supplied here is research-grade for in vitro laboratory study only.
Every lot, independently verified
Compound information
Chemical & structural reference data — specifications, molecular profile and handling.
Ipamorelin Mechanism of Action
- Acts as a selective agonist of the growth-hormone secretagogue receptor (GHS-R1a, the ghrelin receptor) on pituitary somatotrophs.
- Stimulates pulsatile growth-hormone release without significant effect on ACTH, cortisol, or prolactin in published models — the basis for its ‘selective GHRP’ classification.
- Synergizes with GHRH-receptor agonists (e.g. CJC-1295, sermorelin) on GH release in paired secretagogue studies.
- Acts through Gq/PLC signaling and intracellular calcium mobilization in receptor-expressing cell models.
- The Aib and D-amino-acid residues confer protease resistance relative to native ghrelin-derived sequences.
- Carries no melanocortin or opioid receptor activity, isolating GHS-R1a pharmacology as a research tool.
Ipamorelin Research Applications
- GHS-R1a receptor-binding and activation assays in receptor-expressing cell lines.
- Pituitary somatotroph GH-release studies in cell-culture and rodent models.
- Comparative GHRP vs GHRH secretagogue synergy experiments.
- Calcium-mobilization and Gq/PLC signaling assays.
- Selectivity profiling against ACTH, cortisol, and prolactin readouts.
- Structure-activity studies of GHS-R1a pentapeptide agonists.
Why Buy Ipamorelin from Koi Peptides?
- Every batch of Koi ipamorelin is synthesized and lyophilized in the United States, then released against independent third-party laboratory (Freedom Diagnostics Testing) testing.
- Each lot is tested by HPLC for purity, LC-MS for identity confirmation, and endotoxin assay for sterility readiness.
- The lot ID is printed on every vial and ties back to a public COA library, so researchers can verify documentation before they buy and after the vial arrives.
- Orders placed before 2 PM CT ship the same business day, and shipping is free on orders over $200.
References
View all references+
- Raun, K., et al. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology, 139(5), 552–561. doi.org/10.1530/eje.0.1390552
- Kojima, M., & Kangawa, K. (2005). Ghrelin: structure and function. Endocrine Reviews / Physiological Reviews, 85(2), 495–522. doi.org/10.1210/er.2004-0014
- Kojima, M., et al. (1999). Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 402(6762), 656–660. doi.org/10.1038/45230
Regulatory Status
For research use only. Not for human or veterinary use. Ipamorelin is supplied to qualified research professionals for in vitro laboratory study. It has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease. Koi Research Labs LLC is a chemical supplier, not a compounding pharmacy under 503A nor an outsourcing facility under 503B of the Federal Food, Drug, and Cosmetic Act. By purchasing, the buyer agrees this material will not be introduced into humans or animals. Misuse may violate federal, state, or local laws.
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