Sermorelin 10mg & 5mg (10mg Vial)
$96.00
A synthetic 29-amino-acid analog of growth-hormone-releasing hormone (GHRH 1-29), supplied as sterile lyophilized powder for in-vitro endocrinology research.
In stock
Tested by Freedom Diagnostics TestingHPLC purity + LC-MS identityLot-matched COA on-site
For research use only. This product is a laboratory research chemical. It is not for human or veterinary use, not a drug, supplement, or food, and not intended to diagnose, treat, cure, or prevent any disease. Sold only to qualified researchers and institutions.
What is Sermorelin?
Sermorelin is a synthetic peptide corresponding to the N-terminal 1-29 residues of growth-hormone-releasing hormone (GHRH), the minimal fragment that retains full GH-releasing activity. It binds the GHRH receptor (GHRH-R) on pituitary somatotrophs and signals through the Gs / adenylyl-cyclase / cAMP pathway, the physiological trigger for growth-hormone synthesis and release. Because it acts upstream of the pituitary, it preserves the pulsatile pattern of GH release in physiological models, distinguishing it from direct GH administration.
Research areas where laboratories buy Sermorelin for in vitro work include GHRH-R binding and cAMP-accumulation assays in receptor-expressing cells, pituitary somatotroph GH-release studies in cell culture and rodent models, GHRH/GHRP secretagogue synergy experiments (for example with Ipamorelin), structure-activity studies of GHRH(1-29) fragments and analogs, and comparative analysis against longer-acting GHRH analogs such as tesamorelin and CJC-1295.
Every lot, independently verified
Compound information
Chemical & structural reference data — specifications, molecular profile and handling.
Product Specifications
Molecular Profile
Storage & Handling
Sermorelin Mechanism of Action
- Binds the growth-hormone-releasing-hormone receptor (GHRH-R) on pituitary somatotrophs, the physiological trigger for GH synthesis and release.
- Signals through Gs / adenylyl-cyclase / cAMP, raising intracellular cAMP and stimulating GH gene transcription and secretion.
- Corresponds to the N-terminal 1-29 residues of native GHRH, the minimal fragment that retains full GH-releasing activity.
- Acts upstream of, and synergizes with, GHS-R1a (ghrelin-receptor) agonists such as Ipamorelin in paired secretagogue studies.
- Preserves the pulsatile pattern of GH release in physiological models, distinguishing it from direct GH administration.
- Subject to enzymatic cleavage at the N-terminus, a structure-activity consideration addressed by longer-acting GHRH analogs.
Sermorelin Research Applications
- GHRH-R binding and cAMP-accumulation assays in receptor-expressing cells.
- Pituitary somatotroph GH-release studies in cell culture and rodent models.
- GHRH/GHRP secretagogue synergy experiments (e.g. with Ipamorelin).
- Structure-activity studies of GHRH(1-29) fragments and analogs.
- Pulsatile GH-secretion modeling under defined conditions.
- Comparative analysis against longer-acting GHRH analogs (e.g. tesamorelin, CJC-1295).
Why Buy Sermorelin from Koi Peptides?
- Every batch of Koi Sermorelin is synthesized and lyophilized in the United States, then released against independent third-party laboratory (Freedom Diagnostics Testing) testing.
- Each lot is tested by HPLC for purity, LC-MS for identity confirmation, and endotoxin assay for sterility readiness.
- The lot ID is printed on every vial and ties back to a public COA library, so researchers can verify documentation before they buy and after the vial arrives.
- Orders placed before 2 PM CT ship the same business day, and shipping is free on orders over $200.
- Guillemin, R., et al. (1982). Growth hormone-releasing factor from a human pancreatic islet tumor. Science, 218(4572), 585–587. doi.org/10.1126/science.6812220
- Mayo, K. E., et al. (1995). Growth hormone-releasing hormone and its receptor. Endocrine Reviews, 16(1), 1–30. doi.org/10.1210/edrv-16-1-1
- Thorner, M. O., et al. (1983). GRF(1-29)NH2 stimulates growth hormone secretion. Journal of Clinical Endocrinology & Metabolism, 57(2), 367–370.
Regulatory Status
FDA StatusSermorelin acetate was previously FDA-approved as the prescription drug product Geref (sermorelin acetate, originally from Serono), used as a growth-hormone stimulation test and for pediatric growth-hormone deficiency, but the branded product was discontinued from the U.S. market around 2008. It is no longer marketed as an FDA-approved finished drug; sermorelin is presently supplied to patients in the United States only through state-licensed compounding pharmacies. The research-grade material supplied by Koi Peptides is synthesized independently for in vitro laboratory research only — not formulated, packaged, or labeled for human use, not equivalent to or a substitute for any approved or compounded drug, and not authorized for any human or veterinary indication.
WADA Anti-Doping StatusSermorelin is prohibited in sport at all times under Section S2 of the WADA Prohibited List, which covers peptide hormones, growth factors, related substances and mimetics — including growth-hormone secretagogues and GHRH and its analogs. Athletes subject to anti-doping testing should be aware that GHRH(1-29) analogs such as sermorelin fall within this prohibited class.
Compounding Pharmacy StatusKoi Peptides is a chemical research supplier — not a compounding pharmacy or outsourcing facility under sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act — and supplies no compounded preparations of any kind. While sermorelin is presently dispensed to patients through licensed compounding pharmacies, the research-grade material supplied here is not a compounded preparation and is for in vitro laboratory use only.
For research use only. Not for human or veterinary use. Sermorelin is supplied to qualified research professionals for in vitro laboratory study. It has not been evaluated by the FDA in this form and is not intended to diagnose, treat, cure, or prevent any disease. By purchasing, the buyer agrees this material will not be introduced into humans or animals. Misuse may violate federal, state, or local laws.
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