Subtotal: $35.00
Kisspeptin-10 10mg & 5mg (Kp-10) (5mg Vial)
$50.00
A KISS1-derived decapeptide (Kp-10) that activates the KISS1R (GPR54) receptor upstream of GnRH, supplied as 5 mg sterile lyophilized powder for in-vitro reproductive-endocrinology research.
In stock
Tested by Freedom Diagnostics TestingHPLC purity + LC-MS identityLot-matched COA on-site
For research use only. This product is a laboratory research chemical. It is not for human or veterinary use, not a drug, supplement, or food, and not intended to diagnose, treat, cure, or prevent any disease. Sold only to qualified researchers and institutions.
What is Kisspeptin-10?
Kisspeptin-10 (Kp-10) is a synthetic decapeptide (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂) corresponding to the C-terminal active fragment of the KISS1 gene product, also known as metastin. It is an agonist of the KISS1R receptor (GPR54) and retains the full receptor-activating activity of the parent kisspeptin. The C-terminal Arg-Phe-NH₂ (RFamide) motif is essential for receptor activation.
Research areas where laboratories buy kisspeptin-10 for in vitro work include KISS1R (GPR54) binding and calcium-mobilization assays in receptor-expressing cells, GnRH-neuron activation studies in hypothalamic cell-culture and slice models, hypothalamic-pituitary-gonadal (HPG) axis modeling with downstream LH/FSH readouts, and structure-activity studies of the kisspeptin C-terminal RFamide motif. Kisspeptin remains an investigational compound in reproductive-endocrinology research; the material supplied here is research-grade for in vitro laboratory study only.
Every lot, independently verified
Independently third-party tested and matched to the lot ID printed on your vial. Values below are from the latest released lot.
99.26%
HPLC-UV Purity
Passed full QC panel
independent third-party lab (Freedom Diagnostics Testing) accredited lab
Latest batch · tested 23 Mar 2026 · Freedom Diagnostics (USA)
Lot details
ProductKisspeptin-10 5 mg
LotRed Cap
AppearanceWhite lyophilized powder
Accession #2603200302
Reported23 Mar 2026
Full QC panel · ISO 170257 assays
Purity (HPLC-UV)99.26% ✓
Identity (LC-MS)Kisspeptin ✓
HPLC conformity (2×)Confirmed ✓
Net content5.09 mg ✓
Heavy metals (ICP-MS)Not Detected ✓
SterilityNo Growth ✓
Endotoxin (USP <85>)Within limits ✓
Every lot is released against Koi’s full QC panel — HPLC purity, LC-MS identity, net content, heavy metals, sterility, and endotoxin — by an independent ISO/IEC 17025-accredited laboratory. Values shown are from the latest released lot and vary batch to batch. The lot-specific certificate is published in our public COA library and matched to the lot ID printed on the vial.
Compound information
Chemical & structural reference data — specifications, molecular profile and handling.
Product Specifications
CompoundKisspeptin-10 (KISS1R / GPR54 decapeptide agonist)
Vial size5 mg
Purity≥99% by HPLC
Identity confirmationMass spectrometry
FormWhite lyophilized powder
Appearance after reconstitutionClear, colorless solution
ManufacturingSynthesized and lyophilized in the United States
Quality testingIndependent independent third-party laboratory release
Molecular Profile
SequenceTyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
FragmentKISS1 (112-121) / metastin (45-54)
Molecular weight1302.5 g/mol
CAS number374675-21-5
ReceptorKISS1R (GPR54)
Structure classDecapeptide · C-terminal amide
Storage & Handling
AppearanceWhite lyophilized powder
SolubilitySterile water · neutral pH
Storage · powder−20 °C, desiccated, dark (−80 °C long-term)
In solution2–8 °C; aliquot & freeze, avoid freeze-thaw
Kisspeptin-10 Mechanism of Action
- Activates the KISS1R (GPR54) receptor — the C-terminal decapeptide retains the full receptor-activating activity of the parent kisspeptin.
- Signals through Gq/PLC, mobilizing intracellular calcium in receptor-expressing cells.
- Acts on hypothalamic GnRH neurons to drive GnRH release, positioning kisspeptin upstream of the hypothalamic-pituitary-gonadal (HPG) axis.
- Drives downstream LH and FSH secretion in physiological models via GnRH.
- The C-terminal Arg-Phe-NH₂ (RFamide) motif is essential for receptor activation.
- Serves as the reference KISS1R agonist for separating kisspeptin-driven from direct GnRH-driven effects.
Kisspeptin-10 Research Applications
- KISS1R (GPR54) binding and calcium-mobilization assays in receptor-expressing cells.
- GnRH-neuron activation studies in hypothalamic cell-culture and slice models.
- HPG-axis modeling — downstream LH/FSH readouts in rodent systems.
- Structure-activity studies of the kisspeptin C-terminal RFamide motif.
- Reproductive-endocrinology and puberty-onset research models.
- Comparative work against full-length kisspeptin-54 and shorter fragments.
Why Buy Kisspeptin-10 from Koi Peptides?
- Every batch of Koi kisspeptin-10 is synthesized and lyophilized in the United States, then released against independent third-party laboratory (Freedom Diagnostics Testing) testing.
- Each lot is tested by HPLC for purity, LC-MS for identity confirmation, and endotoxin assay for sterility readiness.
- The lot ID is printed on every vial and ties back to a public COA library, so researchers can verify documentation before they buy and after the vial arrives.
- Orders placed before 2 PM CT ship the same business day, and shipping is free on orders over $200.
View all references+
- Muir, A. I., et al. (2001). AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. Journal of Biological Chemistry, 276(31), 28969–28975. doi.org/10.1074/jbc.M104847200
- Seminara, S. B., et al. (2003). The GPR54 gene as a regulator of puberty. New England Journal of Medicine, 349(17), 1614–1627. doi.org/10.1056/NEJMoa035322
- Pinilla, L., et al. (2012). Kisspeptins and reproduction: physiological roles and regulatory mechanisms. Physiological Reviews, 92(3), 1235–1316. doi.org/10.1152/physrev.00037.2010
Regulatory Status
FDA, WADA anti-doping, and compounding status — provided for research context.
FDA StatusKisspeptin-10 is not approved by the FDA for any indication. It is an investigational peptide studied in reproductive-endocrinology research and early clinical investigation, but it is not an approved drug product. The research-grade material supplied by Koi Peptides is synthesized independently for in vitro laboratory research only — not formulated, packaged, or labeled for human use, not equivalent to any approved drug product, and not authorized for any human or veterinary indication.
WADA Anti-Doping StatusKisspeptin-10 is not currently named on the WADA Prohibited List and is not specifically tracked under the WADA Monitoring Program. As with any substance, athletes subject to anti-doping rules should confirm current status with their governing body and maintain documentation for any approved use.
Compounding Pharmacy StatusKoi Peptides is a chemical research supplier — not a compounding pharmacy or outsourcing facility under sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act — and supplies no compounded preparations of any kind. Because kisspeptin-10 is an unapproved investigational molecule, it is not eligible for pharmacy compounding for human use.
Disclaimer
For research use only. Not for human or veterinary use. Kisspeptin-10 is supplied to qualified research professionals for in vitro laboratory study. It has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease. Koi Research Labs LLC is a chemical supplier, not a compounding pharmacy under 503A nor an outsourcing facility under 503B of the Federal Food, Drug, and Cosmetic Act. By purchasing, the buyer agrees this material will not be introduced into humans or animals. Misuse may violate federal, state, or local laws.
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