MOTS-c 40mg & 10mg (40mg Vial)

Name: MOTS-c 40mg &amp; 10mg (40mg Vial)
SKU: 56
Price: 150.00 USD
Availability: InStock

$150.00

A 16-amino-acid mitochondrial-derived peptide encoded within mitochondrial DNA, supplied as 10 mg of sterile lyophilized powder for in-vitro study.

In stock

Tested by Freedom Diagnostics TestingHPLC purity + LC-MS identityLot-matched COA on-site

For research use only. This product is a laboratory research chemical. It is not for human or veterinary use, not a drug, supplement, or food, and not intended to diagnose, treat, cure, or prevent any disease. Sold only to qualified researchers and institutions.

Category: Longevity & Cellular Health

Description
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What is MOTS-c?

MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MDP), first described in 2015 by Lee and colleagues. Unusually, it is encoded within the human mitochondrial genome — in the 12S rRNA (MT-RNR1) gene region — rather than nuclear DNA, which distinguishes it from most known peptides. It is studied as one of the clearest described examples of mitochondrial-nuclear retrograde signaling, in which a mitochondrially encoded factor translocates to the nucleus to influence gene expression.

Research areas where laboratories buy MOTS-c for in vitro work include AMPK pathway-activation studies with downstream glucose-uptake effects in skeletal-muscle cell models, mitochondrial-nuclear retrograde-signaling and nuclear-translocation research under metabolic stress, exercise-mimetic and AICAR-related biosynthesis pathways, and aging-research models relating MOTS-c levels to mitochondrial function. The peptide contains two oxidation-sensitive methionine residues, a structure-activity consideration for assay design and handling.

Every lot, independently verified

Independently third-party tested and matched to the lot ID printed on your vial. Values below are from the latest released lot.

99.62%

HPLC-UV Purity

Passed full QC panel

independent third-party lab (Freedom Diagnostics Testing) accredited lab

Latest batch · tested 10 Feb 2026 · Freedom Diagnostics (USA)

Lot details

ProductMOTS-c 10 mg

LotPer-batch on COA

AppearanceWhite lyophilized powder

Accession #2602060017

Reported10 Feb 2026

Full QC panel · ISO 170257 assays

Purity (HPLC-UV)99.615% ✓

Identity (LC-MS)MOTS-c ✓

HPLC conformity (2×)Confirmed ✓

Net content11.14 mg ✓

Heavy metals (ICP-MS)Not Detected ✓

SterilityNo Growth ✓

Endotoxin (USP <85>)Within limits ✓

Every lot is released against Koi’s full QC panel — HPLC purity, LC-MS identity, net content, heavy metals, sterility, and endotoxin — by an independent ISO/IEC 17025-accredited laboratory. Values shown are from the latest released lot (reported 10 Feb 2026) and vary batch to batch; the lot-specific certificate is published in our public COA library and matched to the lot ID printed on the vial.

Compound information

Chemical & structural reference data — specifications, molecular profile and handling.

Product Specifications

CompoundMOTS-c (16-amino-acid mitochondrial-derived peptide)

Vial size10 mg

Purity≥99% by HPLC

Identity confirmationMass spectrometry

FormWhite lyophilized powder

Appearance after reconstitutionClear, colorless solution

ManufacturingSynthesized and lyophilized in the United States

Quality testingIndependent independent third-party laboratory release

Molecular Profile

SequenceMet-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

Molecular formulaC₁₀₁H₁₅₂N₂₈O₂₂S₂

Molecular weight2174.64 g/mol

CAS number1627580-64-6

PubChem CID146675088

EncodingMitochondrial MT-RNR1 (12S rRNA)

Structure class16-aa mitochondrial-derived peptide

Storage & Handling

AppearanceWhite lyophilized powder

SolubilityBacteriostatic water / buffers

Storage · powder−20 °C, desiccated, dark (−80 °C long-term)

In solution2–8 °C; protect Met from oxidation

MOTS-c Mechanism of Action

Activates the AMP-activated protein kinase (AMPK) pathway, a central energy sensor, with downstream effects on glucose uptake in skeletal-muscle cell models.
Translocates to the nucleus under metabolic stress to regulate nuclear gene expression — one of the clearest described examples of mitochondrial-nuclear retrograde signaling.
Modulates fatty-acid and glucose metabolism, feeding into AICAR-related biosynthesis and exercise-mimetic signaling pathways.
Is encoded within mitochondrial DNA (the MT-RNR1 / 12S rRNA region) rather than nuclear DNA — distinguishing it from most known peptides.
Circulating levels rise with physical activity and decline with age, underpinning its use in metabolic and aging-research models.
Contains two oxidation-sensitive methionine residues, a structure-activity consideration for assay design and handling.

MOTS-c Research Applications

AMPK pathway activation and downstream glucose-uptake effects in skeletal-muscle cell models.
Mitochondrial-nuclear retrograde signaling and MOTS-c nuclear translocation under metabolic stress.
Comparative MOTS-c activity in fasting, glucose-restriction, and oxidative-stress in-vitro models.
Exercise-mimetic signaling pathways and AICAR-related biosynthesis in cell culture.
Aging-research models relating MOTS-c levels to mitochondrial function.
Receptor-binding and structure-activity studies under defined buffer and temperature conditions.

Why Buy MOTS-c from Koi Peptides?

Every batch of Koi MOTS-c is synthesized and lyophilized in the United States, then released against independent third-party laboratory (Freedom Diagnostics Testing) testing.
Each lot is tested by HPLC for purity, LC-MS for identity confirmation, and endotoxin assay for sterility readiness.
The lot ID is printed on every vial and ties back to a public COA library, so researchers can verify documentation before they buy and after the vial arrives.
Orders placed before 2 PM CT ship the same business day, and shipping is free on orders over $200.

Lee, C., et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443–454. doi.org/10.1016/j.cmet.2015.02.009
Kim, K. H., et al. (2018). MOTS-c translocates to the nucleus to regulate gene expression under metabolic stress. Cell Metabolism, 28(3), 516–524. doi.org/10.1016/j.cmet.2018.06.008
Reynolds, J. C., et al. (2021). MOTS-c is an exercise-induced regulator of age-dependent physical decline. Nature Communications, 12, 470. doi.org/10.1038/s41467-020-20790-0
Merry, T. L., et al. (2020). Mitochondrial-derived peptides in energy metabolism. Am. J. Physiol. Endocrinol. Metab., 319(4), E659–E666. doi.org/10.1152/ajpendo.00249.2020
Kim, S. J., et al. (2017). Mitochondrial-derived peptides in aging and age-related diseases. Trends Endocrinol. Metab., 28(2), 143–152. doi.org/10.1016/j.tem.2016.10.005
Lu, H., et al. (2021). MOTS-c and metabolic regulation of mitochondrial-nuclear communication. Free Radic. Biol. Med., 165, 73–82. doi.org/10.1016/j.freeradbiomed.2021.01.007

Regulatory Status

FDA, WADA anti-doping, and compounding status — provided for research context.

FDA StatusMOTS-c is not approved by the FDA for any indication. It is an unapproved research compound and has not been evaluated by the FDA for safety or efficacy. The research-grade material supplied by Koi Peptides is synthesized for in vitro laboratory research only — not formulated, packaged, or labeled for human use, and not authorized for any human or veterinary indication.

WADA Anti-Doping StatusMOTS-c is not specifically named on the WADA Prohibited List by compound name; however, AMPK-activating agents are addressed under the WADA List, and researchers should consult the current WADA List directly, as classifications are reviewed annually. This information is provided for research context only and does not constitute compliance advice.

Compounding Pharmacy StatusKoi Peptides is a chemical research supplier — not a compounding pharmacy or outsourcing facility under sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act — and supplies no compounded preparations of any kind. As an unapproved research compound, MOTS-c is not eligible for pharmacy compounding for human use.

Disclaimer

For research use only. Not for human or veterinary use. MOTS-c is supplied to qualified research professionals for in vitro laboratory study. It has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease. Koi Research Labs LLC is a chemical supplier, not a compounding pharmacy under 503A nor an outsourcing facility under 503B of the Federal Food, Drug, and Cosmetic Act. By purchasing, the buyer agrees this material will not be introduced into humans or animals. Misuse may violate federal, state, or local laws.

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