What is CJC-1295 + Ipamorelin?
CJC-1295 + Ipamorelin (No DAC) is a co-lyophilized blend of two synthetic peptides that act as a dual growth-hormone secretagogue system. CJC-1295 (no DAC) is a modified GRF(1-29), a growth-hormone-releasing-hormone (GHRH) analog that binds the GHRH receptor on pituitary somatotrophs, while Ipamorelin is a selective growth-hormone-releasing peptide (GHRP) that binds the ghrelin receptor (GHS-R1a). Because the two peptides engage different receptors on the same cells, laboratories use the blend as a reference GHRH-plus-GHRP combination for studying synergistic GH release.
Research areas where laboratories buy this blend for in vitro work include GHRH-R and GHS-R1a co-activation studies on pituitary somatotrophs, GH-release synergy experiments comparing single versus dual secretagogues, cAMP and calcium-mobilization signaling assays, and selectivity profiling against ACTH, cortisol, and prolactin readouts. Neither component is an FDA-approved drug.
Every lot, independently verified
Endotoxin (USP <85>)Within limits ✓
Compound information
Chemical & structural reference data — specifications, molecular profile and handling.
Product Specifications
Molecular Profile
Storage & Handling
In solution2–8 °C; aliquot & freeze, avoid freeze-thaw
CJC-1295 + Ipamorelin Mechanism of Action
- CJC-1295 (no DAC) binds the GHRH receptor on pituitary somatotrophs, signaling through Gαs / cAMP to stimulate GH synthesis and release.
- Ipamorelin binds the ghrelin receptor (GHS-R1a), acting through Gq/PLC and calcium mobilization on the same somatotrophs.
- The two receptor mechanisms are complementary — GHRH-R and GHS-R1a agonism synergize on GH release in paired secretagogue studies.
- Ipamorelin’s selectivity keeps ACTH, cortisol, and prolactin readouts largely unaffected.
- The ‘no DAC’ CJC-1295 (modified GRF 1-29) lacks the drug-affinity-complex, giving a shorter-acting GHRH profile than DAC versions.
- Used as the reference GHRH+GHRP dual-secretagogue tool combination.
CJC-1295 + Ipamorelin Research Applications
- GHRH-R and GHS-R1a co-activation studies on pituitary somatotrophs.
- GH-release synergy experiments comparing single versus dual secretagogues.
- cAMP and calcium-mobilization signaling assays.
- Selectivity profiling against ACTH/cortisol/prolactin readouts.
- Pulsatile GH-secretion modeling under defined conditions.
- Structure-activity studies of GHRH-analog plus GHRP combinations.
Why Buy CJC-1295 + Ipamorelin from Koi Peptides?
- Every batch of Koi CJC-1295 + Ipamorelin is synthesized and lyophilized in the United States, then released against independent third-party laboratory (Freedom Diagnostics Testing) testing.
- Each lot is tested by HPLC for purity, LC-MS for identity confirmation, and endotoxin assay for sterility readiness.
- The lot ID is printed on every vial and ties back to a public COA library, so researchers can verify documentation before they buy and after the vial arrives.
- Orders placed before 2 PM CT ship the same business day, and shipping is free on orders over $200.
References
View all references+
- Raun, K., et al. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology, 139(5), 552–561. doi.org/10.1530/eje.0.1390552
- Teichman, S. L., et al. (2006). Prolonged stimulation of growth hormone and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GHRH. Journal of Clinical Endocrinology & Metabolism, 91(3), 799–805. doi.org/10.1210/jc.2005-1536
- Mayo, K. E., et al. (1995). Growth hormone-releasing hormone and its receptor. Endocrine Reviews, 16(1), 1–36. doi.org/10.1210/edrv-16-1-1
Regulatory Status
FDA StatusNeither component of this blend is an FDA-approved drug. CJC-1295 (modified GRF 1-29) and Ipamorelin are growth-hormone secretagogues that have not been approved by the FDA for any indication. The research-grade material supplied by Koi Peptides is synthesized independently for in vitro laboratory research only — not formulated, packaged, or labeled for human use, not equivalent to any approved or investigational drug product, and not authorized for any human or veterinary indication.
WADA Anti-Doping StatusGrowth-hormone secretagogues — including GHRH and its analogs such as CJC-1295, and growth-hormone-releasing peptides (GHRPs) such as Ipamorelin — are prohibited at all times under section S2 of the WADA Prohibited List (Peptide Hormones, Growth Factors, Related Substances and Mimetics). Both components of this blend fall within that class, so the combination is prohibited for athletes under WADA jurisdiction, in and out of competition. There is no general Therapeutic Use Exemption for these substances.
Compounding Pharmacy StatusKoi Peptides is a chemical research supplier — not a compounding pharmacy or outsourcing facility under sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act — and supplies no compounded preparations of any kind. Because neither component is an FDA-approved substance, the blend is not eligible for pharmacy compounding for human use.
For research use only. Not for human or veterinary use. CJC-1295 + Ipamorelin (No DAC) is supplied to qualified research professionals for in vitro laboratory study. It has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease. Koi Research Labs LLC is a chemical supplier, not a compounding pharmacy under 503A nor an outsourcing facility under 503B of the Federal Food, Drug, and Cosmetic Act. By purchasing, the buyer agrees this material will not be introduced into humans or animals. Misuse may violate federal, state, or local laws.
Frequently Asked Questions About CJC-1295 + Ipamorelin
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